Wyck is an architecturally innovative house with an old-fashioned skin. From the outside it appears colonial in plan and design with some fashionable accents such as the late 18th-century whitewashed stucco.

The house is actually an accumulation of 18th-century parts: the hall (c. 1700-20), the front parlor (1736) and the library and dining room from (1771-73, which replaced a c.1690 log structure.)

The house has been little altered since 1824 when Philadelphia architect William Strickland dramatically rearranged its interior spaces to create an open plan, allowing light to flood each room and bringing the pleasures of the garden inside.